CATH Classification

Domain Context

CATH Clusters

Superfamily 2.30.30.60
Functional Family

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P00383
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P00383
DYR21_ECOLX
Escherichia coli
Dihydrofolate reductase type 2

PDB Structure

PDB 2RK2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of a type II dihydrofolate reductase catalytic ternary complex.
Krahn, J.M., Jackson, M.R., DeRose, E.F., Howell, E.E., London, R.E.
Biochemistry