CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family

Enzyme Information

1.14.13.218
5-methylphenazine-1-carboxylate 1-monooxygenase.
based on mapping to UniProt Q9HWG9
5-methylphenazine-1-carboxylate + NADH + O(2) = pyocyanine + NAD(+) + CO(2) + H(2)O.
-!- The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is involved in the biosynthesis of pyocyanin, a toxin produced and secreted by the organism. -!- It can also act on phenazine-1-carboxylate, converting it into 1-hydroxyphenazine.

UniProtKB Entries (1)

Q9HWG9
PHZS_PSEAE
Pseudomonas aeruginosa PAO1
5-methylphenazine-1-carboxylate 1-monooxygenase

PDB Structure

PDB 2RGJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Pyocyanin Biosynthetic Protein PhzS.
Greenhagen, B.T., Shi, K., Robinson, H., Gamage, S., Bera, A.K., Ladner, J.E., Parsons, J.F.
Biochemistry