CATH Classification

Domain Context

CATH Clusters

Superfamily 2.80.10.50
Functional Family Beta-galactoside-specific lectin 1

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P81446
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P81446
ML1_VISAL
Viscum album
Beta-galactoside-specific lectin 1

PDB Structure

PDB 2RG9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of viscum album mistletoe lectin I in native state at 1.95 A resolution, comparison of structure active site conformation in ricin and in viscumin
Karpechenko, N.U., Timofeev, V.I., Gabdoulkhakov, A.G., Mikhailov, A.M.
To be Published