CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.37
Leukocyte elastase.
based on mapping to UniProt P08246
Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.
-!- Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.7 and EC 3.4.21.11.

UniProtKB Entries (1)

P08246
ELNE_HUMAN
Homo sapiens
Neutrophil elastase

PDB Structure

PDB 2RG3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives.
Huang, W., Yamamoto, Y., Li, Y., Dou, D., Alliston, K.R., Hanzlik, R.P., Williams, T.D., Groutas, W.C.
J.Med.Chem.