CATH Classification

Domain Context

CATH Clusters

Superfamily Pseudouridine synthase
Functional Family H/ACA ribonucleoprotein complex subunit CBF5

Enzyme Information

5.4.99.25
tRNA pseudouridine(55) synthase.
based on mapping to UniProt Q7LWY0
tRNA uridine(55) = tRNA pseudouridine(55).
-!- Pseudourine synthase TruB from Escherichia coli specifically modifies uridine(55) in tRNA molecules. -!- The bifunctional archaeal enzyme also catalyzes the pseudouridylation of uridine(54). -!- It is not known whether the enzyme from Escherichia coli can also act on position 54 in vitro, since this position is occupied in E.coli tRNAs by thymine.

UniProtKB Entries (1)

Q7LWY0
TRUB_PYRFU
Pyrococcus furiosus DSM 3638
Probable tRNA pseudouridine synthase B

PDB Structure

PDB 2RFK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Substrate RNA positioning in the archaeal H/ACA ribonucleoprotein complex.
Liang, B., Xue, S., Terns, R.M., Terns, M.P., Li, H.
Nat.Struct.Mol.Biol.