CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.390.30
Functional Family Glutathione reductase

Enzyme Information

1.8.1.16
Glutathione amide reductase.
based on mapping to UniProt D0VWY5
2 glutathione amide + NAD(+) = glutathione amide disulfide + NADH.
-!- The enzyme restores glutathione amide disulfide, which is produced during the reduction of peroxide by EC 1.11.1.17 back to glutathione amide (it catalyzes the reaction in the opposite direction to that shown). -!- The enzyme belongs to the family of flavoprotein disulfide oxidoreductases, but unlike other members of the family, which are specific for NADPH, it prefers NADH.

UniProtKB Entries (1)

D0VWY5
GASHR_MARGR
Marichromatium gracile
Glutathione amide reductase

PDB Structure

PDB 2RAB
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Understanding nicotinamide dinucleotide cofactor and substrate specificity in class I flavoprotein disulfide oxidoreductases: crystallographic analysis of a glutathione amide reductase.
Van Petegem, F., De Vos, D., Savvides, S., Vergauwen, B., Van Beeumen, J.
J.Mol.Biol.