CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Cathepsin S

Enzyme Information

3.4.22.27
Cathepsin S.
based on mapping to UniProt P25774
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
-!- A lysosomal cysteine endopeptidase that is unusual among such enzymes for its stability to neutral pH. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P25774
CATS_HUMAN
Homo sapiens
Cathepsin S

PDB Structure

PDB 2R9O
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Design and Synthesis of Reversible Inhibitors of Cathepsin S: alpha,alpha-Disubstitution at the P1 Residue Provides Potent Inhibitors in Cellular Assays and In Vivo Models of Antigen Presentation
Ward, Y.D., Emmanuel, M.J., Thomson, D.S., Liu, W., Bekkali, Y., Frye, L.L., Girardot, M., Morwick, T., Young, E.R.R., Zindell, R., Hrapchak, M., DeTuri, M., White, A., Crane, K.M., White, D.M., Wang, Y., Hao, M.-H., Grygon, C.A., Labadia, M.E., Wildeson, J., Freeman, D., Nelson, R., Capolino, A., Peterson, J.D., Raymond, E.L., Brown, M.L., Spero, D.M.
to be published