CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.270
Functional Family

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q04049
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q04049
POLH_YEAST
Saccharomyces cerevisiae S288C
DNA polymerase eta

PDB Structure

PDB 2R8K
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta
Alt, A., Lammens, K., Chiocchini, C., Lammens, A., Pieck, J.C., Kuch, D., Hopfner, K.P., Carell, T.
Science