CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.20
Functional Family

Enzyme Information

6.3.4.23
Formate--phosphoribosylaminoimidazolecarboxamide ligase.
based on mapping to UniProt Q8U0R7
ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide.
-!- This archaeal enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyzes a step in the synthesis of purine nucleotides. -!- It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP. -!- Cf. EC 2.1.2.3.

UniProtKB Entries (1)

Q8U0R7
PURP_PYRFU
Pyrococcus furiosus DSM 3638
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase

PDB Structure

PDB 2R85
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
Zhang, Y., White, R.H., Ealick, S.E.
Biochemistry