CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family 3-phosphoinositide-dependent protein kinase 1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O15530
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O15530
PDPK1_HUMAN
Homo sapiens
3-phosphoinositide-dependent protein kinase 1

PDB Structure

PDB 2R7B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Dibenzo[c,f][2,7]naphthyridines as Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 Inhibitors.
Gopalsamy, A., Shi, M., Boschelli, D.H., Williamson, R., Olland, A.M., Hu, Y., Krishnamurthy, G., Han, X., Arndt, K., Guo, B.
J.Med.Chem.