CATH Classification

Domain Context

CATH Clusters

Superfamily TERT catalytic subunit-like
Functional Family

Enzyme Information

2.7.7.49
RNA-directed DNA polymerase.
based on mapping to UniProt O77448
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.

UniProtKB Entries (1)

O77448
TERT_TETTH
Tetrahymena thermophila
Telomerase reverse transcriptase

PDB Structure

PDB 2R4G
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding.
Rouda, S., Skordalakes, E.
Structure