CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P08263
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.
1.11.1.-
Peroxidases.
based on mapping to UniProt P08263
5.3.3.-
Transposing C=C bonds.
based on mapping to UniProt P08263

UniProtKB Entries (1)

P08263
GSTA1_HUMAN
Homo sapiens
Glutathione S-transferase A1

PDB Structure

PDB 2R3X
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Arginine 15 stabilizes an S(N)Ar reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1.
Gildenhuys, S., Dobreva, M., Kinsley, N., Sayed, Y., Burke, J., Pelly, S., Gordon, G.P., Sayed, M., Sewell, T., Dirr, H.W.
Biophys.Chem.