CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P09945
HIRV2_HIRME
Hirudo medicinalis
Hirudin variant-2

PDB Structure

PDB 2R2M
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
2-(2-Chloro-6-Fluorophenyl)Acetamides as Potent Thrombin Inhibitors
Lee, L., Kreutter, K.D., Pan, W., Crysler, C., Spurlino, J., Player, M.R., Tomczuk, B., Lu, T.
Bioorg.Med.Chem.Lett.