CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family

Enzyme Information

3.1.1.81
Quorum-quenching N-acyl-homoserine lactonase.
based on mapping to UniProt A9CKY2
An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine.
-!- Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. -!- Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes. -!- Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL- signaling and the expression of virulence genes in quorum-sensing bacteria. -!- N-(3-oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L- homoserine lactone, N-butanoyl-L-homoserine lactone and N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates.

UniProtKB Entries (1)

A9CKY2
AHLLB_AGRFC
Agrobacterium fabrum str. C58
N-acyl homoserine lactonase AiiB

PDB Structure

PDB 2R2D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and specificity of a quorum-quenching lactonase (AiiB) from Agrobacterium tumefaciens.
Liu, D., Thomas, P.W., Momb, J., Hoang, Q.Q., Petsko, G.A., Ringe, D., Fast, W.
Biochemistry