CATH Domain 2qy6B01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family	tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC

Enzyme Information

2.1.1.61	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase. based on mapping to UniProt Q8XCQ7 S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2- thiouridylate. -!- Specific for the terminal methyl group of 5-methylaminomethyl-2- thiouridylate.
1.5.-.-	Acting on the CH-NH group of donors. based on mapping to UniProt Q8XCQ7

UniProtKB Entries (1)

MNMC_ECO57

Escherichia coli O157:H7

TRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC

PDB Structure

PDB	2QY6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of the N-terminal domain of UPF0209 protein yfcK from Escherichia coli O157:H7. Bonanno, J.B., Dickey, M., Bain, K.T., Eberle, M., Ozyurt, S., Smith, D., Wasserman, S., Sauder, J.M., Burley, S.K., Almo, S.C. To be Published