CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC

Enzyme Information

2.1.1.61
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase.
based on mapping to UniProt Q8XCQ7
S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2- thiouridylate.
-!- Specific for the terminal methyl group of 5-methylaminomethyl-2- thiouridylate.
1.5.-.-
Acting on the CH-NH group of donors.
based on mapping to UniProt Q8XCQ7

UniProtKB Entries (1)

Q8XCQ7
MNMC_ECO57
Escherichia coli O157:H7
TRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC

PDB Structure

PDB 2QY6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the N-terminal domain of UPF0209 protein yfcK from Escherichia coli O157:H7.
Bonanno, J.B., Dickey, M., Bain, K.T., Eberle, M., Ozyurt, S., Smith, D., Wasserman, S., Sauder, J.M., Burley, S.K., Almo, S.C.
To be Published