CATH Domain 2qy0A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.70	Complement Module; domain 1
	2.10.70.10	Complement Module, domain 1

Domain Context

CATH Clusters

Superfamily	Complement Module, domain 1
Functional Family	Complement C1r subcomponent

Enzyme Information

3.4.21.41

Complement subcomponent C1r.

based on mapping to UniProt P00736

Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).

-!- Activates C1s by proteolytic cleavage so that it can, in turn, activate C2 and C4. -!- Activated from proenzyme C1r in plasma by autocatalytic mechanism during activation of the complement system by the 'classical' route. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00736

C1R_HUMAN

Homo sapiens

Complement C1r subcomponent

PDB Structure

PDB	2QY0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r. Kardos, J., Harmat, V., Pallo, A., Barabas, O., Szilagyi, K., Graf, L., Naray-Szabo, G., Goto, Y., Zavodszky, P., Gal, P. Mol.Immunol.