CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Serine/threonine-protein kinase receptor

Enzyme Information

2.7.11.30
Receptor protein serine/threonine kinase.
based on mapping to UniProt Q13705
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q13705
AVR2B_HUMAN
Homo sapiens
Activin receptor type-2B

PDB Structure

PDB 2QLU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of activin receptor type IIB kinase domain from human at 2.0 Angstrom resolution
Han, S., Loulakis, P., Griffor, M., Xie, Z.
Protein Sci.