CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family Ribonuclease H1

Enzyme Information

3.1.26.4
Ribonuclease H.
based on mapping to UniProt O60930
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.

UniProtKB Entries (1)

O60930
RNH1_HUMAN
Homo sapiens
Ribonuclease H1

PDB Structure

PDB 2QK9
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Nowotny, M., Gaidamakov, S.A., Ghirlando, R., Cerritelli, S.M., Crouch, R.J., Yang, W.
Mol.Cell