CATH Classification
Domain Context
CATH Clusters
| Superfamily | RIG-I-like receptor, C-terminal regulatory domain |
| Functional Family | Probable ATP-dependent RNA helicase DDX58 |
Enzyme Information
| 3.6.4.13 |
RNA helicase.
based on mapping to UniProt O95786
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
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UniProtKB Entries (1)
| O95786 |
DDX58_HUMAN
Homo sapiens
Probable ATP-dependent RNA helicase DDX58
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PDB Structure
| PDB | 2QFD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I.
Mol.Cell
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