CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
6 | Special |
|
6.10 | Helix non-globular |
|
6.10.250 | Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
|
6.10.250.110 |
Domain Context
CATH Clusters
| Superfamily | 6.10.250.110 |
| Functional Family |
Enzyme Information
| 5.6.2.2 |
DNA topoisomerase.
based on mapping to UniProt P14565
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.
|
| 3.6.4.12 |
DNA helicase.
based on mapping to UniProt P14565
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).
|
UniProtKB Entries (1)
| P14565 |
TRAI1_ECOLI
Escherichia coli K-12
Multifunctional conjugation protein TraI
|
PDB Structure
| PDB | 2Q7U |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase.
Proc.Natl.Acad.Sci.Usa
|