CATH Classification

Domain Context

CATH Clusters

Superfamily S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal
Functional Family Adenosyl-chloride synthase

Enzyme Information

2.5.1.94
Adenosyl-chloride synthase.
based on mapping to UniProt A4X3Q0
S-adenosyl-L-methionine + chloride = 5-deoxy-5-chloroadenosine + L-methionine.
-!- This enzyme, isolated from the marine bacterium Salinispora tropica, catalyzes an early step in the pathway leading to biosynthesis of the proteosome inhibitor salinosporamide A. -!- The enzyme is very similar to EC 2.5.1.63 but does not accept fluoride.

UniProtKB Entries (1)

A4X3Q0
SALL_SALTO
Salinispora tropica CNB-440
Adenosyl-chloride synthase

PDB Structure

PDB 2Q6I
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Discovery and characterization of a marine bacterial SAM-dependent chlorinase
Eustaquio, A.S., Pojer, F., Noel, J.P., Moore, B.S.
Nat.Chem.Biol.