CATH Classification

Domain Context

CATH Clusters

Superfamily Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain
Functional Family 3-hydroxy-3-methylglutaryl coenzyme A reductase

Enzyme Information

1.1.1.34
Hydroxymethylglutaryl-CoA reductase (NADPH).
based on mapping to UniProt P04035
(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.
-!- The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47.

UniProtKB Entries (1)

P04035
HMDH_HUMAN
Homo sapiens
3-hydroxy-3-methylglutaryl-coenzyme A reductase

PDB Structure

PDB 2Q6C
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.
Pfefferkorn, J.A., Choi, C., Song, Y., Trivedi, B.K., Larsen, S.D., Askew, V., Dillon, L., Hanselman, J.C., Lin, Z., Lu, G., Robertson, A., Sekerke, C., Auerbach, B., Pavlovsky, A., Harris, M.S., Bainbridge, G., Caspers, N.
Bioorg.Med.Chem.Lett.