CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family U5 small nuclear ribonucleoprotein kDa helicase

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt O75643
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

O75643
U520_HUMAN
Homo sapiens
U5 small nuclear ribonucleoprotein 200 kDa helicase

PDB Structure

PDB 2Q0Z
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Q9P172/Sec63 from Homo sapiens.
Benach, J., Neely, H., Abashidze, M., Edstrom, W.C., Seetharaman, J., Zhao, L., Fang, Y., Cunningham, K., Owens, L., Ma, L.-C., Xiao, R., Liu, J., Baran, M.C., Acton, T.B., Rost, B., Montelione, G.T., Tong, L., Hunt, J.F.
To be Published