CATH Classification

Domain Context

CATH Clusters

Superfamily DNA polymerase; domain 6
Functional Family DNA polymerase

Enzyme Information

3.1.11.-
Exodeoxyribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt P03680
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P03680
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P03680
DPOL_BPPH2
Bacillus virus phi29
DNA polymerase

PDB Structure

PDB 2PYL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases
Berman, A.J., Kamtekar, S., Goodman, J.L., Lazaro, J.M., de Vega, M., Blanco, L., Salas, M., Steitz, T.A.
Embo J.