CATH Classification

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family

Enzyme Information

2.7.7.60
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
based on mapping to UniProt Q5SLX2
CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
-!- ATP or UTP can replace CTP, but both are less effective. -!- GTP and TTP are not substrates. -!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

Q5SLX2
ISPD_THET8
Thermus thermophilus HB8
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

PDB Structure

PDB 2PX7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase from Thermus thermophilus HB8.
Chen, L., Tsukuda, M., Ebihara, A., Shinkai, A., Kuramitsu, S., Yokoyama, S., Chen, L.-Q., Liu, Z.-J., Lee, D., Chang, S.-H., Nguyen, D., Rose, J.P., Wang, B.-C.
To be Published