CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Fibroblast growth factor receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P21802
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P21802
FGFR2_HUMAN
Homo sapiens
Fibroblast growth factor receptor 2

PDB Structure

PDB 2PWL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Chen, H., Ma, J., Li, W., Eliseenkova, A.V., Xu, C., Neubert, T.A., Miller, W.T., Mohammadi, M.
Mol.Cell