CATH Classification

Domain Context

CATH Clusters

Superfamily Thrombin light chain domain
Functional Family

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P19221
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P19221
THRB_MOUSE
Mus musculus
Prothrombin

PDB Structure

PDB 2PV9
External Links
Method X-RAY DIFFRACTION
Organism Cricetulus
Primary Citation
Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4.
Bah, A., Chen, Z., Bush-Pelc, L.A., Mathews, F.S., Di Cera, E.
Proc.Natl.Acad.Sci.Usa