1 keywords

CATH Domain 2pv7A02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.3660 6-phosphogluconate dehydrogenase C-terminal fold
Homologous Superfamily 1.10.3660.10 6-phosphogluconate dehydrogenase C-terminal like domain

Domain Context

CATH Clusters

Superfamily 6-phosphogluconate dehydrogenase C-terminal like domain
Functional Family T-protein

Enzyme Information

1.3.1.12
Prephenate dehydrogenase.
based on mapping to UniProt P43902
Prephenate + NAD(+) = 4-hydroxyphenylpyruvate + CO(2) + NADH.
-!- This enzyme in the enteric bacteria also possesses EC 5.4.99.5 activity and converts chorismate into prephenate.
5.4.99.5
Chorismate mutase.
based on mapping to UniProt P43902
Chorismate = prephenate.

UniProtKB Entries (1)

P43902
TYRA_HAEIN
Haemophilus influenzae Rd KW20
T-protein

PDB Structure

PDB 2PV7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes.
Chiu, H.J., Abdubek, P., Astakhova, T., Axelrod, H.L., Carlton, D., Clayton, T., Das, D., Deller, M.C., Duan, L., Feuerhelm, J., Grant, J.C., Grzechnik, A., Han, G.W., Jaroszewski, L., Jin, K.K., Klock, H.E., Knuth, M.W., Kozbial, P., Krishna, S.S., Kumar, A., Marciano, D., McMullan, D., Miller, M.D., Morse, A.T., Nigoghossian, E., Okach, L., Reyes, R., Tien, H.J., Trame, C.B., van den Bedem, H., Weekes, D., Xu, Q., Hodgson, K.O., Wooley, J., Elsliger, M.A., Deacon, A.M., Godzik, A., Lesley, S.A., Wilson, I.A.
Acta Crystallogr.,Sect.F