CATH Classification

Domain Context

CATH Clusters

Superfamily Porin chaperone SurA, peptide-binding domain
Functional Family Chaperone SurA

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P0ABZ6
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P0ABZ6
SURA_ECOLI
Escherichia coli K-12
Chaperone SurA

PDB Structure

PDB 2PV3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Periplasmic Bacterial Molecular Chaperone SurA Adapts its Structure to Bind Peptides in Different Conformations to Assert a Sequence Preference for Aromatic Residues.
Xu, X., Wang, S., Hu, Y.X., McKay, D.B.
J.Mol.Biol.