CATH Classification

Domain Context

CATH Clusters

Superfamily Glucose-6-phosphate isomerase like protein; domain 1
Functional Family Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Enzyme Information

2.6.1.16
Glutamine--fructose-6-phosphate transaminase (isomerizing).
based on mapping to UniProt P53704
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.
-!- Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination). -!- Formerly EC 5.3.1.19.

UniProtKB Entries (1)

P53704
GFA1_CANAL
Candida albicans SC5314
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

PDB Structure

PDB 2PUW
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The Crystal and Solution Studies of Glucosamine-6-phosphate Synthase from Candida albicans
Raczynska, J., Olchowy, J., Konariev, P.V., Svergun, D.I., Milewski, S., Rypniewski, W.
J.Mol.Biol.