CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P15214
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P15214
GST_PROMI
Proteus mirabilis
Glutathione S-transferase GST-6.0

PDB Structure

PDB 2PMT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A mixed disulfide bond in bacterial glutathione transferase: functional and evolutionary implications.
Rossjohn, J., Polekhina, G., Feil, S.C., Allocati, N., Masulli, M., De Illio, C., Parker, M.W.
Structure