CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Gag-Pol polyprotein

Enzyme Information

UniProtKB Entries (1)

Q9Q2G8
Q9Q2G8_9HIV1
Human immunodeficiency virus 1
V-1 protease

PDB Structure

PDB 2PK6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Compensating enthalpic and entropic changes hinder binding affinity optimization.
Lafont, V., Armstrong, A.A., Ohtaka, H., Kiso, Y., Mario Amzel, L., Freire, E.
Chem.Biol.Drug Des.