CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.281
GDP-4-dehydro-6-deoxy-D-mannose reductase.
based on mapping to UniProt Q6T1X6
GDP-alpha-D-rhamnose + NAD(P)(+) = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H.
-!- Differs from EC 1.1.1.187 in that the only product formed is GDP- alpha-D-rhamnose (GDP-6-deoxy-alpha-D-mannose). -!- D-rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.

UniProtKB Entries (1)

Q6T1X6
RMD_ANETH
Aneurinibacillus thermoaerophilus
GDP-6-deoxy-D-mannose reductase

PDB Structure

PDB 2PK3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway.
King, J.D., Poon, K.K., Webb, N.A., Anderson, E.M., McNally, D.J., Brisson, J.R., Messner, P., Garavito, R.M., Lam, J.S.
Febs J.