CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.330.10
Functional Family Cell division control 48

Enzyme Information

3.6.4.6
Vesicle-fusing ATPase.
based on mapping to UniProt Q01853
ATP + H(2)O = ADP + phosphate.
-!- A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. -!- They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. -!- They include peroxin, which apparently is involved in Zellweger's syndrome.

UniProtKB Entries (1)

P60670
NPL4_MOUSE
Mus musculus
Nuclear protein localization protein 4 homolog

PDB Structure

PDB 2PJH
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Detailed structural insights into the p97-Npl4-Ufd1 interface.
Isaacson, R.L., Pye, V.E., Simpson, P., Meyer, H.H., Zhang, X., Freemont, P.S., Matthews, S.
J.Biol.Chem.