CATH Classification

Domain Context

CATH Clusters

Superfamily Ureohydrolase domain
Functional Family Arginase-1

Enzyme Information

3.5.3.1
Arginase.
based on mapping to UniProt P05089
L-arginine + H(2)O = L-ornithine + urea.
-!- Also hydrolyzes alpha-N-substituted L-arginines and canavanine.

UniProtKB Entries (1)

P05089
ARGI1_HUMAN
Homo sapiens
Arginase-1

PDB Structure

PDB 2PHO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster.
Di Costanzo, L., Pique, M.E., Christianson, D.W.
J.Am.Chem.Soc.