CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.6
Coagulation factor Xa.
based on mapping to UniProt P00742
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
-!- A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. -!- Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. -!- The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids. -!- Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00742
FA10_HUMAN
Homo sapiens
Coagulation factor X

PDB Structure

PDB 2PHB
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an orally efficacious factor Xa inhibitor
Kohrt, J.T., Bigge, C.F., Bryant, J.W., Casimiro-Garcia, A., Chi, L., Cody, W.L., Dahring, T., Dudley, D.A., Filipski, K.J., Haarer, S., Heemstra, R., Janiczek, N., Narasimhan, L., McClanahan, T., Peterson, J.T., Sahasrabudhe, V., Schaum, R., Van Huis, C.A., Welch, K.M., Zhang, E., Leadley, R.J., Edmunds, J.J.
Chem.Biol.Drug Des.