CATH Classification

Domain Context

CATH Clusters

Superfamily N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family 6-phosphogluconate dehydrogenase, decarboxylating

Enzyme Information

1.1.1.44
Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).
based on mapping to UniProt P00349
6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
-!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343.

UniProtKB Entries (1)

P00349
6PGD_SHEEP
Ovis aries
6-phosphogluconate dehydrogenase, decarboxylating

PDB Structure

PDB 2PGD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of 6-phosphogluconate dehydrogenase refined at 2.5 A resolution.
Adams, M.J., Gover, S., Leaback, R., Phillips, C., Somers, D.O.
Acta Crystallogr.,Sect.B