CATH Classification

Domain Context

CATH Clusters

Superfamily Formiminotetrahydrofolate cyclodeaminase monomer, up-and-down helical bundle
Functional Family Formimidoyltransferase cyclodeaminase

Enzyme Information

4.3.1.4
Formimidoyltetrahydrofolate cyclodeaminase.
based on mapping to UniProt O88618
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH(3).
-!- In eukaroytes, occurs as a bifunctional enzyme that also has EC 2.1.2.5 activity.
2.1.2.5
Glutamate formimidoyltransferase.
based on mapping to UniProt O88618
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.
-!- In eukaryotes occurs as a bifunctional enzyme also having EC 4.3.1.4 activity. -!- Formerly EC 2.1.2.6.

UniProtKB Entries (1)

O88618
FTCD_RAT
Rattus norvegicus
Formimidoyltransferase-cyclodeaminase

PDB Structure

PDB 2PFD
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Anisotropically refined structure of FTCD
Poon, B.K., Chen, X., Lu, M., Vyas, N.K., Quiocho, F.A., Wang, Q., Ma, J.
To be Published