CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.190.80
Functional Family

Enzyme Information

3.1.3.25
Inositol-phosphate phosphatase.
based on mapping to UniProt O67791
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
-!- Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. -!- It also acts on adenosine 2'-phosphate (but not the 3'- or 5'-phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate, but does not act on inositol bisphosphates or more phosphorylated inositols.
3.1.3.11
Fructose-bisphosphatase.
based on mapping to UniProt O67791
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
-!- The animal enzyme also acts on sedoheptulose 1,7-bisphosphate.

UniProtKB Entries (1)

O67791
BSUHB_AQUAE
Aquifex aeolicus VF5
Fructose-1,6-bisphosphatase/inositol-1-monophosphatase

PDB Structure

PDB 2PCR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Myo-inositol-1(or 4)-monophosphatase (aq_1983) from Aquifex Aeolicus VF5
Jeyakanthan, J., Gayathri, D., Velmurugan, D., Agari, Y., Bessho, Y., Ellis, M.J., Antonyuk, S.V., Strange, R.W., Hasnain, S.S., Ebihara, A., Kuramitsu, S., Shinkai, A., Shiro, Y., Yokoyama, S.
To be Published