CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Prostaglandin E synthase 2

Enzyme Information

5.3.99.3
Prostaglandin-E synthase.
based on mapping to UniProt Q9N0A4
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.
-!- Brings about the opening of the epidioxy bridge.

UniProtKB Entries (1)

Q9N0A4
PGES2_MACFA
Macaca fascicularis
Prostaglandin E synthase 2

PDB Structure

PDB 2PBJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme.
Yamada, T., Takusagawa, F.
Biochemistry