CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.47.10
Functional Family

Enzyme Information

2.3.3.10
Hydroxymethylglutaryl-CoA synthase.
based on mapping to UniProt Q01581
Acetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
-!- Formerly EC 4.1.3.5.

UniProtKB Entries (1)

Q01581
HMCS1_HUMAN
Homo sapiens
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

PDB Structure

PDB 2P8U
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
Shafqat, N., Turnbull, A., Zschocke, J., Oppermann, U., Yue, W.W.
J.Mol.Biol.