1 keywords

CATH Domain 2p59A01

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.40 Beta Barrel
Topology 2.40.10 Thrombin, subunit H
Homologous Superfamily 2.40.10.120  

Domain Context

CATH Clusters

Superfamily 2.40.10.120
Functional Family

Enzyme Information

UniProtKB Entries (2)

P27958
POLG_HCVH
Hepatitis C virus (isolate H)
Genome polyprotein
Q91RS4
Q91RS4_9HEPC
Hepacivirus C
NS3 protease

PDB Structure

PDB 2P59
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics.
Perni, R.B., Chandorkar, G., Cottrell, K.M., Gates, C.A., Lin, C., Lin, K., Luong, Y.P., Maxwell, J.P., Murcko, M.A., Pitlik, J., Rao, G., Schairer, W.C., Van Drie, J., Wei, Y.
Bioorg.Med.Chem.Lett.