CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Dual specificity mitogen-activated protein kinase dSOR1

Enzyme Information
Mitogen-activated protein kinase kinase.
based on mapping to UniProt Q02750
ATP + a protein = ADP + a phosphoprotein.
-!- A dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. -!- It is required for activation of EC -!- Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues. -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.

UniProtKB Entries (1)

Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 1

PDB Structure

PDB 2P55
External Links
Organism Escherichia
Primary Citation
4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.
Spicer, J.A., Rewcastle, G.W., Kaufman, M.D., Black, S.L., Plummer, M.S., Denny, W.A., Quin, J., Shahripour, A.B., Barrett, S.D., Whitehead, C.E., Milbank, J.B., Ohren, J.F., Gowan, R.C., Omer, C., Camp, H.S., Esmaeil, N., Moore, K., Sebolt-Leopold, J.S., Pryzbranowski, S., Merriman, R.L., Ortwine, D.F., Warmus, J.S., Flamme, C.M., Pavlovsky, A.G., Tecle, H.