CATH Classification

Domain Context

CATH Clusters

Superfamily 2.30.30.60
Functional Family

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P00383
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P00383
DYR21_ECOLX
Escherichia coli
Dihydrofolate reductase type 2

PDB Structure

PDB 2P4T
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode.
Divya, N., Grifith, E., Narayana, N.
Protein Sci.