CATH Classification

Domain Context

CATH Clusters

Superfamily Fructose-1,6-Bisphosphatase, subunit A, domain 1
Functional Family Fructose-1,6-bisphosphatase/inositol-1-monophosphatase

Enzyme Information

3.1.3.11
Fructose-bisphosphatase.
based on mapping to UniProt O33832
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
-!- The animal enzyme also acts on sedoheptulose 1,7-bisphosphate.
3.1.3.25
Inositol-phosphate phosphatase.
based on mapping to UniProt O33832
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
-!- Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. -!- It also acts on adenosine 2'-phosphate (but not the 3'- or 5'-phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate, but does not act on inositol bisphosphates or more phosphorylated inositols.

UniProtKB Entries (1)

O33832
BSUHB_THEMA
Thermotoga maritima MSB8
Fructose-1,6-bisphosphatase/inositol-1-monophosphatase

PDB Structure

PDB 2P3V
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the tetrameric inositol 1-phosphate phosphatase (TM1415) from the hyperthermophile, Thermotoga maritima.
Stieglitz, K.A., Roberts, M.F., Li, W., Stec, B.
Febs J.