CATH Classification

Domain Context

CATH Clusters

Superfamily S-adenosyl-L-methionine-dependent methyltransferases
Functional Family

Enzyme Information

2.1.1.144
Trans-aconitate 2-methyltransferase.
based on mapping to UniProt Q8UH15
S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate.
-!- Also catalyzes the formation of the methyl monoester of cis- aconitate, isocitrate and citrate, but more slowly. -!- While the enzyme from Escherichia coli forms (E)-3-(methoxycarbonyl)- pent-2-enedioate as the product, that from Saccharomyces cerevisiae forms (E)-2-(methoxycarbonylmethyl)butenedioate and is therefore classified as a separate enzyme (cf. EC 2.1.1.145).

UniProtKB Entries (1)

Q8UH15
TAM_AGRFC
Agrobacterium fabrum str. C58
Trans-aconitate 2-methyltransferase

PDB Structure

PDB 2P35
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of trans-aconitate methyltransferase from Agrobacterium tumefaciens
Chang, C., Xu, X., Zheng, H., Savchenko, A., Joachimiak, A.
To be Published