CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase receptor TYRO3

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q12866
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q12866
MERTK_HUMAN
Homo sapiens
Tyrosine-protein kinase Mer

PDB Structure

PDB 2P0C
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural insights into the inhibited states of the Mer receptor tyrosine kinase.
Huang, X., Finerty, P., Walker, J.R., Butler-Cole, C., Vedadi, M., Schapira, M., Parker, S.A., Turk, B.E., Thompson, D.A., Dhe-Paganon, S.
J.Struct.Biol.