CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase SYK

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P43403
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P43403
ZAP70_HUMAN
Homo sapiens
Tyrosine-protein kinase ZAP-70

PDB Structure

PDB 2OZO
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70.
Deindl, S., Kadlecek, T.A., Brdicka, T., Cao, X., Weiss, A., Kuriyan, J.
Cell(Cambridge,Mass.)