CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family MAP kinase-activated protein kinase 2

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P49137
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (2)

P47811
MK14_MOUSE
Mus musculus
Mitogen-activated protein kinase 14
P49137
MAPK2_HUMAN
Homo sapiens
MAP kinase-activated protein kinase 2

PDB Structure

PDB 2OZA
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
White, A., Pargellis, C.A., Studts, J.M., Werneburg, B.G., Farmer II, B.T.
Proc.Natl.Acad.Sci.Usa